selective ep2 antagonist pf-04 418 948 (Pfizer Inc)
90
Structured Review
Pfizer Inc
selective ep2 antagonist pf-04 418 948
Selective Ep2 Antagonist Pf 04 418 948, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/selective+ep2+antagonist+pf-04+418+948/ponezumab/pm40192498-24-13-8
Average 90 stars, based on 1 article reviews
Selective Ep2 Antagonist Pf 04 418 948, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/selective+ep2+antagonist+pf-04+418+948/ponezumab/pm40192498-24-13-8
Average 90 stars, based on 1 article reviews
selective ep2 antagonist pf-04 418 948 - by Bioz Stars,
2026-09
90/100 stars
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other:Article Title: Discovery of ACT-1002-4271 as a Dual Prostaglandin E2 Receptor 2/Prostaglandin E2 Receptor 4 Antagonist with In Vivo Anti-Tumor Efficacy. Article Snippet: Prostaglandin E2 (PGE2) signaling via receptors prostaglandin E2 receptor 2 (EP2) and prostaglandin E2 receptor 4 (EP4) is involved in various aspects of cancer and has been shown to promote tumor progression, metastasis, and immune evasion.. Inhibition of PGE2 signaling by blockade of the EP2 and EP4 receptors has the potential to counteract the tumor-promoting effects of PGE2.. Herein, the discovery of compound 30 (ACT-1002-4271), a dual EP2/EP4 antagonist with single-digit nanomolar potency on both receptors, is presented. |